Modeling insertional mutagenesis using gene length and expression in murine embryonic stem cells.

High-throughput mutagenesis of the mammalian genome is a powerful means to facilitate analysis of gene function. Gene trapping in embryonic stem cells (ESCs) is the most widely used form of insertional mutagenesis in mammals. However, the rules governing its efficiency are not fully understood, and...

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Autori principali:	Alex S Nord, Karen Vranizan, Whittemore Tingley, Alexander C Zambon, Kristina Hanspers, Loren G Fong, Yan Hu, Peter Bacchetti, Thomas E Ferrin, Patricia C Babbitt, Scott W Doniger, William C Skarnes, Stephen G Young, Bruce R Conklin
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Public Library of Science (PLoS) 2007-07-01
Serie:	PLoS ONE
Accesso online:	http://europepmc.org/articles/PMC1910612?pdf=render
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