Modeling insertional mutagenesis using gene length and expression in murine embryonic stem cells.

High-throughput mutagenesis of the mammalian genome is a powerful means to facilitate analysis of gene function. Gene trapping in embryonic stem cells (ESCs) is the most widely used form of insertional mutagenesis in mammals. However, the rules governing its efficiency are not fully understood, and...

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Principais autores:	Alex S Nord, Karen Vranizan, Whittemore Tingley, Alexander C Zambon, Kristina Hanspers, Loren G Fong, Yan Hu, Peter Bacchetti, Thomas E Ferrin, Patricia C Babbitt, Scott W Doniger, William C Skarnes, Stephen G Young, Bruce R Conklin
Formato:	Artigo
Idioma:	Inglês
Publicado:	Public Library of Science (PLoS) 2007-07-01
Series:	PLoS ONE
Acceso en liña:	http://europepmc.org/articles/PMC1910612?pdf=render
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