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Ligand-dependent enhancer activation indirectly modulates non-target promoters in a chromatin domain

Transcription activation of genes by estrogen is driven by enhancers, which are often located within the same topologically associating domain (TAD) as non-targeted promoters. We investigated how acute enhancer-driven activation affects neighbouring non-target genes within the same TAD. Using single...

Deskribapen osoa

Gorde:
Egile Nagusiak: Darshika Bohra, Zubairul Islam, Sundarraj Nidharshan, Aprotim Mazumder, Dimple Notani
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications Ltd 2026-07-01
Saila:eLife
Gaiak:
breast cancer
estrogen
MCF-7
gene regulation
steroid hormone signaling
transcription
Sarrera elektronikoa:https://elifesciences.org/articles/102417
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