Polydatin ameliorates early brain injury after subarachnoid hemorrhage through up-regulating SIRT1 to suppress endoplasmic reticulum stress

ObjectiveThis study aims to investigate the inhibitory effect of Polydatin (PD) on endoplasmic reticulum (ER) stress following subarachnoid hemorrhage (SAH) and to elucidate the underlying mechanisms.MethodsA standard intravascular puncture model was established to mimic SAH in mice. Neurological fu...

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Ngā kaituhi matua:	Yuwei Han, Guangzhi Hao, Song Han, Tingzhun Zhu, Yushu Dong, Ligang Chen, Xinyu Yang, Xiaoming Li, Hai Jin, Guobiao Liang
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Frontiers Media S.A. 2024-09-01
Rangatū:	Frontiers in Pharmacology
Ngā marau:	Polydatin subarachnoid hemorrhage endoplasmic reticulum stress SIRT1 early brain injury
Urunga tuihono:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1450238/full
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