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Defective insulin secretory response to intravenous glucose in C57Bl/6J compared to C57Bl/6N mice

Objective: The C57Bl/6J (Bl/6J) mouse is the most widely used strain in metabolic research. This strain carries a mutation in nicotinamide nucleotide transhydrogenase (Nnt), a mitochondrial enzyme involved in NADPH production, which has been suggested to lead to glucose intolerance and beta-cell dys...

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Principais autores: Grace Fergusson, Mélanie Éthier, Mélanie Guévremont, Chloé Chrétien, Camille Attané, Erik Joly, Xavier Fioramonti, Marc Prentki, Vincent Poitout, Thierry Alquier
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2014-12-01
Serier:Molecular Metabolism
Fag:
Beta-cell
Insulin secretion
Insulin sensitivity
Genetic background
Mouse strain
Online adgang:http://www.sciencedirect.com/science/article/pii/S221287781400163X
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