Establishment and validation of an endoplasmic reticulum stress reporter to monitor zebrafish ATF6 activity in development and disease

Induction of endoplasmic reticulum (ER) stress is associated with diverse developmental and degenerative diseases. Modified ER homeostasis causes activation of conserved stress pathways at the ER called the unfolded protein response (UPR). ATF6 is a transcription factor activated during ER stress as...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Eric M. Clark, Hannah J. T. Nonarath, Jonathan R. Bostrom, Brian A. Link
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	The Company of Biologists 2020-01-01
Schriftenreihe:	Disease Models & Mechanisms
Schlagworte:	atf6 endoplasmic reticulum stress unfolded protein response zebrafish neurodegeneration
Online-Zugang:	http://dmm.biologists.org/content/13/1/dmm041426
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!