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Xiaoaiping Induces Developmental Toxicity in Zebrafish Embryos Through Activation of ER Stress, Apoptosis and the Wnt Pathway

The aim of the study was to determine the developmental toxicity of the traditional Chinese medicine Xiaoaiping (XAP) and to investigate its underlying mechanism of action. Zebrafish embryos were incubated with 0.4, 0.8, 1.2, and 1.6 mg/mL XAP. Endpoints such as mortality, hatching rate, malformatio...

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Principais autores: Juanjuan Li, Yun Zhang, Kechun Liu, Qiuxia He, Chen Sun, Jian Han, Liwen Han, Qingping Tian
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-11-01
coleção:Frontiers in Pharmacology
Assuntos:
xiaoaiping
zebrafish embryos
developmental toxicity
swimming behavior
endoplasmic reticulum stress
apoptosis
Acesso em linha:https://www.frontiersin.org/article/10.3389/fphar.2018.01250/full
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