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Differential Sensitivity of the Protein Translation Initiation Machinery and mTOR Signaling to <i>MECP2</i> Gain- and Loss-of-Function Involves MeCP2 Isoform-Specific Homeostasis in the Brain

Eukaryotic gene expression is controlled at multiple levels, including gene transcription and protein translation initiation. One molecule with key roles in both regulatory mechanisms is methyl CpG binding protein 2 (MeCP2). <i>MECP2</i> gain- and loss-of-function mutations lead to Rett Syndrome and...

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Principais autores: Marjorie Buist, Nada El Tobgy, Danilo Shevkoplyas, Matthew Genung, Annan Ali Sher, Shervin Pejhan, Mojgan Rastegar
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-04-01
Serier:Cells
Fag:
epigenetics
MeCP2 isoforms
MeCP2E1
gene transcription
BDNF
brain development
Online adgang:https://www.mdpi.com/2073-4409/11/9/1442
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