Differential Sensitivity of the Protein Translation Initiation Machinery and mTOR Signaling to <i>MECP2</i> Gain- and Loss-of-Function Involves MeCP2 Isoform-Specific Homeostasis in the Brain

Eukaryotic gene expression is controlled at multiple levels, including gene transcription and protein translation initiation. One molecule with key roles in both regulatory mechanisms is methyl CpG binding protein 2 (MeCP2). <i>MECP2</i> gain- and loss-of-function mutations lead to Rett Syndrome and...

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Autori principali:	Marjorie Buist, Nada El Tobgy, Danilo Shevkoplyas, Matthew Genung, Annan Ali Sher, Shervin Pejhan, Mojgan Rastegar
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2022-04-01
Serie:	Cells
Soggetti:	epigenetics MeCP2 isoforms MeCP2E1 gene transcription BDNF brain development
Accesso online:	https://www.mdpi.com/2073-4409/11/9/1442
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