Metabolic reprogramming during ineffective erythropoiesis in β-thalassemia/HbE disease
Ineffective erythropoiesis, the main cause of anemia in β-thalassemia disease, is characterized by dramatic expansion of erythroblasts and increased erythroblast cell death. The absence or reduction of β-globin chains causes an accumulation of excess α-globin chains and generates cytotoxic reactive...
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| Principais autores: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2025-09-01
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| coleção: | Experimental and Molecular Pathology |
| Assuntos: | |
| Acesso em linha: | http://www.sciencedirect.com/science/article/pii/S0014480025000309 |
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