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Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader

Sliding clamps are ring-shaped protein complexes that are integral to the DNA replication machinery of all life. Sliding clamps are opened and installed onto DNA by clamp loader AAA+ ATPase complexes. However, how a clamp loader opens and closes the sliding clamp around DNA is still unknown. Here, w...

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Principais autores: Christl Gaubitz, Xingchen Liu, Joshua Pajak, Nicholas P Stone, Janelle A Hayes, Gabriel Demo, Brian A Kelch
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2022-02-01
coleção:eLife
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Acesso em linha:https://elifesciences.org/articles/74175
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