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Structure of the human CTF18−RFC clamp loader bound to PCNA

Sliding clamps like PCNA are crucial processivity factors for replicative polymerases, requiring specific clamp loaders for loading onto DNA. The human alternative clamp loader CTF18–RFC interacts with the leading strand polymerase Pol ε and loads PCNA onto primer/template DNA using its RFC pentamer...

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Furkejuvvon:
Váldodahkkit: Giuseppina R Briola, Mohammad Tehseen, Amani Al-Amodi, Grace Young, Ammar U Danazumi, Phong Quoc Nguyen, Christos G Savva, Mark Hedglin, Samir M Hamdan, Alfredo De Biasio
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: eLife Sciences Publications Ltd 2026-02-01
Ráidu:eLife
Fáttát:
cryo-EM
DNA replication
clamp loaders
sliding clamps
PCNA
Liŋkkat:https://elifesciences.org/articles/103493
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