Urokinase-type plasminogen activator regulates neurodegeneration and neurogenesis but not vascular changes in the mouse hippocampus after status epilepticus

Expression of urokinase-type plasminogen activator (uPA) is increased after brain injury, suggesting that, like in cancer tissue, uPA plays roles in brain remodeling. Here we injured brain with intrahippocampal kainic acid (KA) injection in adult Wt and uPA−/− mice. At 20 days post-injury, uPA−/− mi...

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Principais autores:	Laura Lahtinen, Xavier Ekolle Ndode-Ekane, Filip Barinka, Yumiko Akamine, Mohammed Hossein Esmaeili, Jukka Rantala, Asla Pitkänen
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2010-03-01
Series:	Neurobiology of Disease
Assuntos:	Angiogenesis Epilepsy Epileptogenesis Granule cell dispersion Hippocampus Neurodegeneration
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S0969996109003635
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