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Ligand dependent gene regulation by transient ERα clustered enhancers.

Unliganded Estrogen receptor alpha (ERα) has been implicated in ligand-dependent gene regulation. Upon ligand exposure, ERα binds to several EREs relatively proximal to the pre-marked, unliganded ERα-bound sites and affects transient but robust gene expression. However, the underlying mechanisms are...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Bharath Saravanan, Deepanshu Soota, Zubairul Islam, Sudeshna Majumdar, Rajat Mann, Sweety Meel, Umer Farooq, Kaivalya Walavalkar, Srimonta Gayen, Anurag Kumar Singh, Sridhar Hannenhalli, Dimple Notani
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science (PLoS) 2020-01-01
Schriftenreihe:PLoS Genetics
Online-Zugang:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1008516&type=printable
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