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Protective effect of saikosaponin D against gestational diabetes mellitus via regulating TLR4/MyD88/NF-κB and MAPK signaling pathway

Objective: To examine the protective effect of saikosaponin D against streptozotocin (STZ)-induced gestational diabetes mellitus in female rats. Methods: Intraperitoneal administration of STZ (40 mg/kg) was used for the induction of diabetes in pregnant rats, and rats orally received sikosaponin D (...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Lu-Lu Wang, Chong Yang, Ye-Qing Su, Fang Wang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Wolters Kluwer Medknow Publications 2025-07-01
Schriftenreihe:Asian Pacific Journal of Tropical Biomedicine
Schlagworte:
saikosaponin d
inflammation
antioxidant
tlr4/myd88/nf-κb
mapk signaling pathway
Online-Zugang:https://journals.lww.com/10.4103/apjtb.apjtb_109_25
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