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4-Hydroxy-2-nonenal antimicrobial toxicity is neutralized by an intracellular pathogen

Pathogens encounter numerous antimicrobial responses during infection, including the reactive oxygen species (ROS) burst. ROS-mediated oxidation of host membrane poly-unsaturated fatty acids (PUFAs) generates the toxic alpha-beta carbonyl 4-hydroxy-2-nonenal (4-HNE). Although studied extensively in...

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Principais autores: Hannah Tabakh, Adelle P McFarland, Maureen K Thomason, Alex J Pollock, Rochelle C Glover, Shivam A Zaver, Joshua J Woodward
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2021-05-01
Serier:eLife
Fag:
Listeria monocytogenes
4-HNE
reactive oxygen species
bacterial pathogenesis
Online adgang:https://elifesciences.org/articles/59295
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