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Study of influence of Catha edulis (Khat) chewing on oral pharmacokinetics of irbesartan in rats using a newly developed HPLC-UV method

Khat consumers might use a number of drugs for underlying conditions; however the potential drug-herb interaction between khat and other drugs including Irbesartan (IRB) is unknown. The present study was conducted to evaluate the effects of khat chewing on pharmacokinetic profile of IRB, a commonly...

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Main Authors: Hassan A. Alhazmi, Mustafa A. Bakri, Yahya A. Mohzari, Yousef G. Alshigaify, Mohammed Al Bratty, Sadique A. Javed, Asim Najmi, Ziaur Rehman, Waquar Ahsan, Manal Mohamed Elhassan Taha
Format: Artigo
Language:Inglês
Published: Springer 2022-03-01
Series:Saudi Pharmaceutical Journal
Subjects:
Khat
Irbesartan
HPLC
Pharmacokinetics
Cytochrome P450
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016422000020
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