The Critical Role of 12-Methyl Group of Anthracycline Dutomycin to Its Antiproliferative Activity

Anthracycline dutomycin is a tetracyclic quinone glycoside produced by <i>Streptomyces minoensis</i> NRRL B-5482. SW91 is a C-12 demethylated dutomycin derivative, which was identified in our previous research. In vitro cytotoxicity and apoptosis assays of these two compounds were conducted to demon...

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Hlavní autoři:	Ruoxuan Xu, Dinghang Hu, Jinlian Lin, Jie Tang, Ruoting Zhan, Guiyou Liu, Lei Sun
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2022-05-01
Edice:	Molecules
Témata:	dutomycin anthracycline aromatic methyl group DNA-binding agents molecular docking
On-line přístup:	https://www.mdpi.com/1420-3049/27/10/3348
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