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Pleiotropic effects of BAFF on the senescence-associated secretome and growth arrest

Senescent cells release a variety of cytokines, proteases, and growth factors collectively known as the senescence-associated secretory phenotype (SASP). Sustained SASP contributes to a pattern of chronic inflammation associated with aging and implicated in many age-related diseases. Here, we invest...

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Principais autores: Martina Rossi, Carlos Anerillas, Maria Laura Idda, Rachel Munk, Chang Hoon Shin, Stefano Donega, Dimitrios Tsitsipatis, Allison B Herman, Jennifer L Martindale, Xiaoling Yang, Yulan Piao, Krystyna Mazan-Mamczarz, Jinshui Fan, Luigi Ferrucci, Peter F Johnson, Supriyo De, Kotb Abdelmohsen, Myriam Gorospe
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2023-04-01
Serier:eLife
Fag:
BAFF
SASP
senescence
paracrine
Online adgang:https://elifesciences.org/articles/84238
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