Cell-targeted gene modification by delivery of CRISPR-Cas9 ribonucleoprotein complexes in pseudotyped lentivirus-derived nanoparticles

To fully utilize the potential of CRISPR-Cas9-mediated genome editing, time-restricted and targeted delivery is crucial. By modulating the pseudotype of engineered lentivirus-derived nanoparticles (LVNPs), we demonstrate efficient cell-targeted delivery of Cas9/single guide RNA (sgRNA) ribonucleopro...

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Xehetasun bibliografikoak

Egile Nagusiak:	Ian Helstrup Nielsen, Anne Bruun Rovsing, Jacob Hørlück Janns, Emil Aagaard Thomsen, Albert Ruzo, Andreas Bøggild, Frederikke Nedergaard, Charlotte Thornild Møller, Thomas Boesen, Søren Egedal Degn, Jagesh V. Shah, Jacob Giehm Mikkelsen
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Elsevier 2024-12-01
Saila:	Molecular Therapy: Nucleic Acids
Gaiak:	Delivery LVNP Gag virus-like particle, VLP, CRISPR-Cas9 pseudotyping cell-targeted gene modification
Sarrera elektronikoa:	http://www.sciencedirect.com/science/article/pii/S2162253124002051
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