Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis
NCOA4 is a selective cargo receptor for the autophagic turnover of ferritin, a process critical for regulation of intracellular iron bioavailability. However, how ferritinophagy flux is controlled and the roles of NCOA4 in iron-dependent processes are poorly understood. Through analysis of the NCOA4...
Sparad:
| Huvudupphov: | , , , , , , , , , |
|---|---|
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
eLife Sciences Publications Ltd
2015-10-01
|
| Serie: | eLife |
| Ämnen: | |
| Länkar: | https://elifesciences.org/articles/10308 |
| Taggar: |
Inga taggar, Lägg till första taggen!
|