Functional screening identifies kinesin spindle protein inhibitor filanesib as a potential treatment option for hepatoblastoma

Abstract Hepatoblastoma is a rare pediatric liver malignancy usually treated with surgery and chemotherapy. To explore new treatment options for hepatoblastoma, drug screening was performed using six cell models established from aggressive hepatoblastoma tumors and healthy pediatric primary hepatocy...

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Detalhes bibliográficos

Principais autores:	Ruth Nousiainen, Katja Eloranta, Jani Saarela, Antti Hassinen, Tamara J. Luck, Stefano Cairo, Emilie Indersie, Swapnil Potdar, Michaela J. Feodoroff, Jouko Lohi, Lassi Paavolainen, David B. Wilson, Vilja Pietiäinen, Markku Heikinheimo, Marjut Pihlajoki
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-04-01
coleção:	npj Precision Oncology
Acesso em linha:	https://doi.org/10.1038/s41698-025-00915-8
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