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The related coactivator complexes SAGA and ATAC control embryonic stem cell self-renewal through acetyltransferase-independent mechanisms

Summary: SAGA (Spt-Ada-Gcn5 acetyltransferase) and ATAC (Ada-two-A-containing) are two related coactivator complexes, sharing the same histone acetyltransferase (HAT) subunit. The HAT activities of SAGA and ATAC are required for metazoan development, but the role of these complexes in RNA polymerase...

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Principais autores: Veronique Fischer, Damien Plassard, Tao Ye, Bernardo Reina-San-Martin, Matthieu Stierle, Laszlo Tora, Didier Devys
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021-08-01
coleção:Cell Reports
Assuntos:
mouse embryonic stem cells
coactivator complexes
SAGA
ATAC
Pol II transcription
4sU labeling
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2211124721010366
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