Mechanism of minocycline activating Nrf2/Hmox1 pathway to prevent ferroptosis and alleviate acute compartment syndrome

Abstract Background Acute compartment syndrome(ACS) is a perilous consequence of trauma. Acute compartment syndrome’s precise cause is yet unknown. We performed studies to confirm that acute compartment syndrome can be relieved by suppressing ferroptosis and activating the Nrf2/Hmox1 pathway. Method...

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Detalhes bibliográficos

Principais autores:	Xiong Liao, Zhao Huang, He Ling, Wencai Li, Junjie Liu, Yonghui Lao, Wei Su
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-10-01
coleção:	Journal of Orthopaedic Surgery and Research
Assuntos:	Acute compartment syndrome Nrf2/Hmox1 signaling pathway Ferroptosis Prognosis
Acesso em linha:	https://doi.org/10.1186/s13018-024-05183-z
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