Mechanism of minocycline activating Nrf2/Hmox1 pathway to prevent ferroptosis and alleviate acute compartment syndrome

Abstract Background Acute compartment syndrome(ACS) is a perilous consequence of trauma. Acute compartment syndrome’s precise cause is yet unknown. We performed studies to confirm that acute compartment syndrome can be relieved by suppressing ferroptosis and activating the Nrf2/Hmox1 pathway. Method...

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Autores principales:	Xiong Liao, Zhao Huang, He Ling, Wencai Li, Junjie Liu, Yonghui Lao, Wei Su
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2024-10-01
Colección:	Journal of Orthopaedic Surgery and Research
Materias:	Acute compartment syndrome Nrf2/Hmox1 signaling pathway Ferroptosis Prognosis
Acceso en línea:	https://doi.org/10.1186/s13018-024-05183-z
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