Development of a UPLC-MS/MS method and its application for the pharmacokinetic analysis of regorafenib in rats

Abstract Regorafenib (REG) is a multikinase inhibitor commonly used in the management of hepatocellular carcinoma, gastrointestinal stromal tumors, and colorectal cancer. Nevertheless, adverse effects or insufficient efficacy appear frequently due to individual variability of plasma concentration of...

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Detalhes bibliográficos

Principais autores:	Filip Otto, Viktoriia Propisnova, Hanna Urjasz, Konrad Lewandowski, Konrad Sarnowski, Edyta Szałek, Agnieszka Karbownik
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2026-02-01
coleção:	Scientific Reports
Assuntos:	Regorafenib Regorafenib N-oxide N-desmethyl regorafenib N-oxide Trametinib UPLC-MS/MS Pharmacokinetics
Acesso em linha:	https://doi.org/10.1038/s41598-026-38418-6
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