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Development of a UPLC-MS/MS method and its application for the pharmacokinetic analysis of regorafenib in rats

Abstract Regorafenib (REG) is a multikinase inhibitor commonly used in the management of hepatocellular carcinoma, gastrointestinal stromal tumors, and colorectal cancer. Nevertheless, adverse effects or insufficient efficacy appear frequently due to individual variability of plasma concentration of...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Filip Otto, Viktoriia Propisnova, Hanna Urjasz, Konrad Lewandowski, Konrad Sarnowski, Edyta Szałek, Agnieszka Karbownik
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Nature Portfolio 2026-02-01
Rangatū:Scientific Reports
Ngā marau:
Urunga tuihono:https://doi.org/10.1038/s41598-026-38418-6
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