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DNA Amplification by Breakage/Fusion/Bridge Cycles Initiated by Spontaneous Telomere Loss in a Human Cancer Cell Line

The development of genomic instability is an important step in generatingthe multiple genetic changes required for cancer. One consequence of genomic instability is the overexpression of oncogenes due to gene amplification. One mechanism for gene amplification is the breakagelfusionlbridge (B/F/B)cy...

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Principais autores: Anthony W.l. Lo, Laure Sabatier, Bijan Fouladi, Géraldine Pottier, Michelle Ricoul, John P. Mumane
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2002-01-01
coleção:Neoplasia: An International Journal for Oncology Research
Assuntos:
chromosome fusion
breakage/fusion/bridge cycles
DNA amplification
telomere
chromosome instability
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1476558602800586
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