A conserved, N-terminal tyrosine signal directs Ras for inhibition by Rabex-5.
Dysregulation of the Ras oncogene in development causes developmental disorders, "Rasopathies," whereas mutational activation or amplification of Ras in differentiated tissues causes cancer. Rabex-5 (also called RabGEF1) inhibits Ras by promoting Ras mono- and di-ubiquitination. We report here that...
Kaydedildi:
| Asıl Yazarlar: | , , , , , , , |
|---|---|
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Public Library of Science (PLoS)
2020-06-01
|
| Seri Bilgileri: | PLoS Genetics |
| Online Erişim: | https://doi.org/10.1371/journal.pgen.1008715 |
| Etiketler: |
Etiket eklenmemiş, İlk siz ekleyin!
|