A conserved, N-terminal tyrosine signal directs Ras for inhibition by Rabex-5.
Dysregulation of the Ras oncogene in development causes developmental disorders, "Rasopathies," whereas mutational activation or amplification of Ras in differentiated tissues causes cancer. Rabex-5 (also called RabGEF1) inhibits Ras by promoting Ras mono- and di-ubiquitination. We report here that...
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| Principais autores: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science (PLoS)
2020-06-01
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| Series: | PLoS Genetics |
| Acceso en liña: | https://doi.org/10.1371/journal.pgen.1008715 |
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