Insight into rifampicin resistance behind discordant mutations in RpoB of Mycobacterium tuberculosis: A molecular dynamics simulations study

The discordance between phenotypic and molecular methods of rifampicin (RIF) drug susceptibility testing may lead to misdiagnosis and mistreatment. In this study, we aimed to find the effects of discordant mutations on RNA polymerase (RNAP) β-subunit (RpoB) thermodynamic properties leading RIF resis...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Muhammad Tahir Khan, Elise Dumont, Jialou Zhu, Kashif Iqbal Sahibzada, Madeeha Shahzad Lodhi, Mehmood Qadir, Dongqing Wei
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2025-07-01
Schriftenreihe:	Results in Chemistry
Schlagworte:	RpoB Rifampicin Discordant mutations
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2211715625003637
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