Insight into rifampicin resistance behind discordant mutations in RpoB of Mycobacterium tuberculosis: A molecular dynamics simulations study

The discordance between phenotypic and molecular methods of rifampicin (RIF) drug susceptibility testing may lead to misdiagnosis and mistreatment. In this study, we aimed to find the effects of discordant mutations on RNA polymerase (RNAP) β-subunit (RpoB) thermodynamic properties leading RIF resis...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Muhammad Tahir Khan, Elise Dumont, Jialou Zhu, Kashif Iqbal Sahibzada, Madeeha Shahzad Lodhi, Mehmood Qadir, Dongqing Wei
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Elsevier 2025-07-01
Цуврал:	Results in Chemistry
Нөхцлүүд:	RpoB Rifampicin Discordant mutations
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S2211715625003637
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!