Metabolic checkpoint of ferroptosis resistance
The metabolic checkpoint of ferroptosis remains obscure. We find that glucose favors system xc− inhibitor-induced ferroptosis by activating pyruvate oxidation, thereby promoting fatty acid synthesis and subsequent lipid peroxidation. In contrast, the upregulation of pyruvate dehydrogenase kinase 4 (...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Taylor & Francis Group
2021-05-01
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| Schriftenreihe: | Molecular & Cellular Oncology |
| Schlagworte: | |
| Online-Zugang: | http://dx.doi.org/10.1080/23723556.2021.1901558 |
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