Metabolic checkpoint of ferroptosis resistance
The metabolic checkpoint of ferroptosis remains obscure. We find that glucose favors system xc− inhibitor-induced ferroptosis by activating pyruvate oxidation, thereby promoting fatty acid synthesis and subsequent lipid peroxidation. In contrast, the upregulation of pyruvate dehydrogenase kinase 4 (...
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| Główni autorzy: | , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Taylor & Francis Group
2021-05-01
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| Seria: | Molecular & Cellular Oncology |
| Hasła przedmiotowe: | |
| Dostęp online: | http://dx.doi.org/10.1080/23723556.2021.1901558 |
| Etykiety: |
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