Immunodepletion experiments suggest that acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1) protein plays a major catalytic role in adult human liver, adrenal gland, macrophages, and kidney, but not in intestines

The first acyl-coenzyme A:cholesterol acyltransferase (ACAT) cDNA cloned and expressed in 1993 is designated as ACAT-1. In various human tissue homogenates, ACAT-1 protein is effectively solubilized with retention of enzymatic activity by the detergent CHAPS along with high salt. After using anti-AC...

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Autores principales:	Oneil Lee, Catherine C.Y. Chang, William Lee, Ta-Yuan Chang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 1998-08-01
Colección:	Journal of Lipid Research
Materias:	cholesteryl esters hepatocytes membrane protein solubilization detergents
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S0022227520322033
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