Lithocholic acid induces endoplasmic reticulum stress, autophagy and mitochondrial dysfunction in human prostate cancer cells

Lithocholic acid (LCA) is a secondary bile acid that is selectively toxic to human neuroblastoma, breast and prostate cancer cells, whilst sparing normal cells. We previously reported that LCA inhibited cell viability and proliferation and induced apoptosis and necrosis of androgen-dependent LNCaP a...

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Autori principali:	Ahmed A. Gafar, Hossam M. Draz, Alexander A. Goldberg, Mohamed A. Bashandy, Sayed Bakry, Mahmoud A. Khalifa, Walid AbuShair, Vladimir I. Titorenko, J. Thomas Sanderson
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	PeerJ Inc. 2016-11-01
Serie:	PeerJ
Soggetti:	Lithocholic acid Prostate cancer cells Pc-3 Du-145 Autophagy Endoplasmic reticulum stress
Accesso online:	https://peerj.com/articles/2445.pdf
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