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Lithocholic acid induces endoplasmic reticulum stress, autophagy and mitochondrial dysfunction in human prostate cancer cells

Lithocholic acid (LCA) is a secondary bile acid that is selectively toxic to human neuroblastoma, breast and prostate cancer cells, whilst sparing normal cells. We previously reported that LCA inhibited cell viability and proliferation and induced apoptosis and necrosis of androgen-dependent LNCaP a...

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Principais autores: Ahmed A. Gafar, Hossam M. Draz, Alexander A. Goldberg, Mohamed A. Bashandy, Sayed Bakry, Mahmoud A. Khalifa, Walid AbuShair, Vladimir I. Titorenko, J. Thomas Sanderson
Format: Artigo
Sprog:Inglês
Udgivet: PeerJ Inc. 2016-11-01
Serier:PeerJ
Fag:
Lithocholic acid
Prostate cancer cells
Pc-3
Du-145
Autophagy
Endoplasmic reticulum stress
Online adgang:https://peerj.com/articles/2445.pdf
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