Ctf4 organizes sister replisomes and Pol α into a replication factory

The current view is that eukaryotic replisomes are independent. Here we show that Ctf4 tightly dimerizes CMG helicase, with an extensive interface involving Psf2, Cdc45, and Sld5. Interestingly, Ctf4 binds only one Pol α-primase. Thus, Ctf4 may have evolved as a trimer to organize two helicases and...

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Principais autores:	Zuanning Yuan, Roxana Georgescu, Ruda de Luna Almeida Santos, Daniel Zhang, Lin Bai, Nina Y Yao, Gongpu Zhao, Michael E O'Donnell, Huilin Li
格式:	Artigo
语言:	Inglês
出版:	eLife Sciences Publications Ltd 2019-10-01
丛编:	eLife
主题:	replication factory CMG helicase Ctf4 DNA replication sister replication forks nucleosomes
在线阅读:	https://elifesciences.org/articles/47405
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