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Assembly of recombinant tau into filaments identical to those of Alzheimer’s disease and chronic traumatic encephalopathy

Abundant filamentous inclusions of tau are characteristic of more than 20 neurodegenerative diseases that are collectively termed tauopathies. Electron cryo-microscopy (cryo-EM) structures of tau amyloid filaments from human brain revealed that distinct tau folds characterise many different diseases...

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Auteurs principaux: Sofia Lövestam, Fujiet Adrian Koh, Bart van Knippenberg, Abhay Kotecha, Alexey G Murzin, Michel Goedert, Sjors HW Scheres
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications Ltd 2022-03-01
Collection:eLife
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Accès en ligne:https://elifesciences.org/articles/76494
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