Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau

Abstract Mice transgenic for human mutant P301S tau are widely used as models for human tauopathies. They develop neurodegeneration and abundant filamentous inclusions made of human mutant four-repeat tau. Here we used electron cryo-microscopy (cryo-EM) to determine the structures of tau filaments f...

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Hauptverfasser:	Manuel Schweighauser, Alexey G. Murzin, Jennifer Macdonald, Isabelle Lavenir, R. Anthony Crowther, Sjors H.W. Scheres, Michel Goedert
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2023-10-01
Schriftenreihe:	Acta Neuropathologica Communications
Schlagworte:	P301S tau Frontotemporal dementia and parkinsonism linked to chromosome 17 Transgenic mice Electron cryo-microscopy
Online-Zugang:	https://doi.org/10.1186/s40478-023-01658-y
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