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Cryo‐EM structures of tau filaments from SH‐SY5Y cells seeded with brain extracts from cases of Alzheimer's disease and corticobasal degeneration

The formation of amyloid filaments through templated seeding is believed to underlie the propagation of pathology in most human neurodegenerative diseases. A widely used model system to study this process is to seed amyloid filament formation in cultured cells using human brain extracts. Here, we re...

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Principais autores: Airi Tarutani, Sofia Lövestam, Xianjun Zhang, Abhay Kotecha, Andrew C. Robinson, David M. A. Mann, Yuko Saito, Shigeo Murayama, Taisuke Tomita, Michel Goedert, Sjors H. W. Scheres, Masato Hasegawa
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2023-08-01
Serier:FEBS Open Bio
Fag:
Alzheimer's disease
amyloid
corticobasal degeneration
electron cryo‐microscopy
SH‐SY5Y
tau
Online adgang:https://doi.org/10.1002/2211-5463.13657
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