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Intratumor heterogeneity and clonal evolution revealed in castration-resistant prostate cancer by longitudinal genomic analysis

Intratumor heterogeneity is a key driver for local relapse and treatment failure. Thus, using multifocal prostate cancer as a model to investigate tumor inter-clonal relationships and tumor evolution could aid in our understanding of drug resistance. Previous studies discovered genomic alterations b...

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Principais autores: Wenhui Zhang, Tao Wang, Yan Wang, Feng Zhu, Haoqing Shi, Jili Zhang, Ziwei Wang, Min Qu, Huaru Zhang, Tianyi Wang, Yuping Qian, Jinjian Yang, Xu Gao, Jing Li
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2022-02-01
coleção:Translational Oncology
Assuntos:
Clonal evolution
CRPC
Drug resistance
Intratumor heterogeneity
Precision medicine
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1936523321003028
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