Resolving intra-tumor heterogeneity and clonal evolution of core-binding factor acute myeloid leukemia patients with single-cell resolution

Abstract Reconstructing and understanding intra-tumor heterogeneity, the coexistence of multiple genetically distinct subclones within the tumor of a patient, and tumor development is essential for resolving carcinogenesis and for identifying mechanisms of therapy resistance. While bulk sequencing c...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Raphael Hablesreiter, Paulina M. Strzelecka, Klara Kopp, Natalia Estrada, Anna Dolnik, Marlon Tilgner, Coral Fustero-Torre, Felicitas Thol, Florian H. Heidel, Michael Heuser, Laleh Haghverdi, Lars Bullinger, Friederike Christen, Frederik Damm
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	BMC 2025-10-01
Σειρά:	Experimental Hematology & Oncology
Θέματα:	AML CBF Intra-tumor heterogeneity Clonal evolution Clonal heterogeneity Single-cell DNA sequencing
Διαθέσιμο Online:	https://doi.org/10.1186/s40164-025-00718-4
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