Thrombospondin-1 inhibits alternative complement pathway activation in antineutrophil cytoplasmic antibody-associated vasculitis

Complement activation is a relevant driver in the pathomechanisms of vasculitis. The involved proteins in the interaction between endothelia, complement, and platelets in these conditions are only partially understood. Thrombospondin-1 (TSP-1), found in platelet α-granules and released from activate...

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Autores principales:	Swagata Konwar, Sophie Schroda, Manuel Rogg, Jessika Kleindienst, Eva L. Decker, Martin Pohl, Barbara Zieger, Jens Panse, Hong Wang, Robert Grosse, Christoph Schell, Sabine Vidal, Xiaobo Liu, Christian Gorzelanny, Todor Tschongov, Karsten Häffner
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Clinical Investigation 2025-07-01
Colección:	The Journal of Clinical Investigation
Materias:	Immunology Inflammation Vascular biology
Acceso en línea:	https://doi.org/10.1172/JCI180062
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