Obesity reduced survival with 5-fluorouracil and did not protect against chemotherapy-induced cachexia or immune cell cytotoxicity in mice

Fluorouracil/5-flourouracil (5FU) is a first-line chemotherapy drug for many cancer types; however, its associated toxicities contribute to poor quality of life and reduced dose intensities negatively impacting patient prognosis. While obesity remains a critical risk factor for most cancers, our und...

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Hauptverfasser:	Brandon N. VanderVeen, Thomas D. Cardaci, Sierra J. McDonald, Sarah S. Madero, Christian A. Unger, Brooke M. Bullard, Reilly T. Enos, Kandy T. Velázquez, Jason L. Kubinak, Daping Fan, E. Angela Murphy
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis Group 2022-12-01
Schriftenreihe:	Cancer Biology & Therapy
Schlagworte:	chemotherapy inflammation skeletal muscle adipose tissue liver toxicity
Online-Zugang:	http://dx.doi.org/10.1080/15384047.2022.2108306
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