LXR agonist rescues synaptic dysfunction and degeneration in SPG3A patient-specific iPSC-derived neurons
Abstract Hereditary spastic paraplegias (HSPs) comprise a large, heterogeneous group of inherited disorders characterized by length-dependent axonal degeneration of corticospinal motor neurons, leading to lower extremity spasticity and gait impairment. Currently, there are no effective treatments fo...
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| Autores principales: | , , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
BMC
2025-11-01
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| Colección: | Acta Neuropathologica Communications |
| Materias: | |
| Acceso en línea: | https://doi.org/10.1186/s40478-025-02134-5 |
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