High throughput profiling of the B cell repertoire identifies systematic changes in the repertoire of individuals with Crohn’s disease

The B cell repertoire contains the recombined sequences that encode the entire antibody repertoire of an individual. The repertoire is made from three antigenic binding chains, namely the immunoglobulin heavy chain (IGH) and two immunoglobulin light chains, κ (IGK) and λ (IGL). Compared to the T cel...

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Bibliografiske detaljer

Principais autores:	Aya K. H. Mahdy, Zahra Taheri, Marte Lie Høivik, Andre Franke, Hesham ElAbd
Format:	Artigo
Sprog:	Inglês
Udgivet:	Frontiers Media S.A. 2026-02-01
Serier:	Frontiers in Immunology
Fag:	B cell B cell repertoire sequencing IBD Ig isotype somatic hypermutation treatment-naïve
Online adgang:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1725813/full
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