Comprehensive analysis of αβT-cell receptor repertoires reveals signatures of thymic selection

Thymic selection is crucial for forming a pool of T-cells that can efficiently discriminate self from non-self using their T-cell receptors (TCRs) to develop adaptive immunity. In the present study we analyzed how a diverse set of physicochemical and sequence features of a TCR can affect the chances...

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Autori principali:	Daniil V. Luppov, Elizaveta K. Vlasova, Dmitry M. Chudakov, Mikhail Shugay
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2025-09-01
Serie:	Frontiers in Immunology
Soggetti:	thymic selection immune repertoire sequencing immune repertoire analysis T-cell immunity T-cell receptor repertoire HLA alleles
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1605170/full
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