Synthesis of Functionalized Isoquinolone Derivatives via Rh(III)-Catalyzed [4+2]-Annulation of Benzamides with Internal Acetylene-Containing α-CF₃-α-Amino Carboxylates

A convenient pathway to a new series of α-CF₃-substituted α-amino acid derivatives bearing pharmacophore isoquinolone core in their backbone has been developed. The method is based on [4+2]-annulation of <i>N-</i>(pivaloyloxy) aryl amides with orthogonally protected internal acetylene-con...

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Autores principales:	Daria V. Vorobyeva, Dmitry A. Petropavlovskikh, Ivan A. Godovikov, Fedor M. Dolgushin, Sergey N. Osipov
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2022-12-01
Colección:	Molecules
Materias:	acetylenes amino acids C-H activation annulation catalysis isoquinolones
Acceso en línea:	https://www.mdpi.com/1420-3049/27/23/8488
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