Synthesis of Functionalized Isoquinolone Derivatives via Rh(III)-Catalyzed [4+2]-Annulation of Benzamides with Internal Acetylene-Containing α-CF₃-α-Amino Carboxylates

A convenient pathway to a new series of α-CF₃-substituted α-amino acid derivatives bearing pharmacophore isoquinolone core in their backbone has been developed. The method is based on [4+2]-annulation of <i>N-</i>(pivaloyloxy) aryl amides with orthogonally protected internal acetylene-con...

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Ngā kaituhi matua:	Daria V. Vorobyeva, Dmitry A. Petropavlovskikh, Ivan A. Godovikov, Fedor M. Dolgushin, Sergey N. Osipov
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	MDPI AG 2022-12-01
Rangatū:	Molecules
Ngā marau:	acetylenes amino acids C-H activation annulation catalysis isoquinolones
Urunga tuihono:	https://www.mdpi.com/1420-3049/27/23/8488
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!